Pain n. : Punishment suffered or denounced; suffering or evil inflicted as a punishment for crime, or connected with the commission of a crime; penalty.

Pain n. : Any uneasy sensation in animal bodies, from slight uneasiness to extreme distress or torture, proceeding from a derangement of functions, disease, or injury by violence; bodily distress; bodily suffering; an ache; a smart.

Pain n. : Specifically, the throes or travail of childbirth.

Pain n. : Uneasiness of mind; mental distress; disquietude; anxiety; grief; solicitude; anguish.

Pain n. : See Pains, labor, effort.

Pain n. : To inflict suffering upon as a penalty; to punish.

Pain n. : To put to bodily uneasiness or anguish; to afflict with uneasy sensations of any degree of intensity; to torment; to torture; as, his dinner or his wound pained him; his stomach pained him.

Pain n. : To render uneasy in mind; to disquiet; to distress; to grieve; as a child's faults pain his parents.

Example:
What Pain reliever is advertised with a man holding the world on his shoulders in a commercial?

Taxonomy
pain, physical pain, injury, animals, nociceptors, lobsters, stimulus, sensation, tissue damage, the brain, feel pain, body, damage, Nociception, pain and suffering, experience pain, chronic pain, fish.

Defination from the web:
pain by various daily hurts and aches, and sometimes through more serious injuries or illnesses. ... Diagnosis is based on characterizing pain in various ways, according to duration, intensity, type (dull, burning, throbbing or stabbing), source, or location in body. ...