Offend v. t. : To strike against; to attack; to assail.

Offend v. t. : To displease; to make angry; to affront.

Offend v. t. : To be offensive to; to harm; to pain; to annoy; as, strong light offends the eye; to offend the conscience.

Offend v. t. : To transgress; to violate; to sin against.

Offend v. t. : To oppose or obstruct in duty; to cause to stumble; to cause to sin or to fall.

Example:
What's the best way to Offend a liberal vegetarian hippie at work?

Taxonomy
Merriam-Webster Online Dictionary, fend, Dictionary, webster, strike, language, Word Games, Webster Online Dictionary with audio pronunciations, Middle English, divine law, vexation, resentment, violation, thesaurus, intransitive verb, transgress, glossary, ESL.

Defination from the web:
offend from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. ... offend need not imply an intentional hurting but it may indicate merely a violation of the victim's sense of what is proper or fitting <hoped ...